Hollis Morgan is offering a Grade II listed 14th-century manor house in Arlingham, Gloucestershire.
Slowwe House has played host to figures including Edward Jenner, inventor of the smallpox vaccine, and Sophie, Countess of Wessex.
The five-bedroom house, guided at £500,000, still has its original servants’ bells.
The sale takes place on 20 July at All Saints Church, Bristol.