Blackstone and Catalyst Capital have put Stratford Island, E15, up for sale.
The £150m opportunity, marketed by Savills, includes the Stratford Centre shopping centre and a development site that has consent for 600 flats across two towers.
It is being offered to around 10 interested parties and the buyer will require both retail and residential expertise.
Consent for the residential towers was secured in February, with construction expected to start this year.
The island site also includes the adjacent 44 Broadway and Morgan House sites. Both are currently used as offices, but planning to convert Morgan House into 130 flats had previously been sought before being withdrawn in late 2014.
Residential rents and house prices in Stratford are expected to outperform the rest of the London market, with JLL forecasting increases of 30% between 2016 and 2020 for houses prices and 28% for rents.
The increases are being led by the continued impact of the 2012 Olympics and the arrival of Crossrail in 2019.
Neil Chegwidden, head of residential research at JLL, said: “Stratford is a vibrant place to live and it has taken massive steps forward. There is a lot of retail, leisure and nightlife, and although there are still areas that need upgrading, it is an appealing place for residents, occupiers and renters and still relatively affordable.”
The 320,000 sq ft Stratford Centre mall is fully let to mostly value brands including Peacocks and New Look. It is in need of refurbishment, but despite being adjacent to the 1.9m sq ft Westfield Stratford City, attracts more than 22m visitors a year.
Blackstone and Catalyst bought the mall from Land Securities for £91.5m in 2010.
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