Andrew Altman, chief executive of the London Legacy Development Corporation, is to step down from the role after the Olympic Games.
He will leave the LLDC after three years as the body enters its legacy phase and its work focuses on construction of housing in the Olympic Park.
“It has been an honour to lead this once-in-a-lifetime project that will transform the face of London and will be a spectacular example of city building the world over,” said Altman.
He added: “I am proud to have been able to set the table with a clear vision, resources and commercial investment. It is now the perfect time to transition the project to one focused on construction, so there will be no disruption after the Games in implementing the legacy vision we have crafted.”
Earlier this year LLDC chair Baroness Margaret Ford stepped down from the firm. She is to be replaced by Daniel Moylan.
A search for a successor to Altman has begun.
Dennis Hone, Olympic Delivery Authority chief executive, has agreed to cover the role at the LLDC on a part-time basis.