Sports Direct parent Frasers Group is closing its House of Fraser store at the Jenners building in Edinburgh.
Frasers said it was unable to agree terms with its landlord, Danish billionaire and retail entrepreneur Anders Povlsen.
The store is set to close on 3 May, resulting in 200 job losses.
A spokesperson for Frasers said: “Despite the global pandemic, numerous lockdowns and the turbulence caused for British retail, the landlord hasn’t been able to work mutually on a fair agreement, therefore, resulting in the loss of 200 jobs and a vacant site for the foreseeable future with no immediate plans.
“Our commitment to our Frasers strategy remains but landlords and retailers need to work together in a fair manner, especially when all stores are closed.”
To send feedback, e-mail pui-guan.man@egi.co.uk or tweet @PuiGuanM or @estatesgazette