Hammerson stocks plummeted by 9.15% following news that John Lewis will not reopen the department store at the iconic Grand Central shopping centre in Birmingham.
The 136,000 sq ft department store is one of eight that John Lewis will permanently close as part of a strategic review.
Hammerson was the biggest loser in the FTSE 250, ending trading at 77.8p.
Elsewhere, housebuilders rallied as the market digested news of stamp duty relief for homebuyers, announced in the summer budget yesterday.
Persimmon topped the rises in the FTSE 100, up by 6.41% to 2,589p, Berkeley rose by 3.8% to 4,400p and Barratt was up by 1.95% to 532.2p.
The FTSE 100 was down by 1.73% to 6,049.62 and the FTSE 250 dipped by 1.16% to 16,985.13.
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