NASDAQ is under offer to take a sub-let at Woolgate Exchange, EC2 from German bank WestLB.
The US stock exchange has agreed terms to lease 30,000 sq ft on the third floor of the building until 2020.
It will pay WestLB a rent of around £42.50.
NASDAQ, which is the world’s second largest stock market by market capitalisation, is based in 131 Finsbury Pavement, EC2, where it has a lease expiry in March 2017.
It appointed Colliers International to search for new City premises earlier this year as part of an expansion plan.
Colliers was awarded a global mandate by NASDAQ OMX, the exchange’s parent company, earlier this year.