Nationwide has gone under offer for the whole of 1 Threadneedle Street, EC2.
The building society will occupy the entire 53,691 sq ft building, taking the majority for its new headquarters and using around 5,000 sq ft for a retail branch.
German fund SEB owns the building, which is close to the Bank of England.
The full terms of the deal have yet to emerge but Nationwide is understood to be paying a rent in the mid £60s per sq ft for the top floors of the building on a 20 year lease with no breaks.
It will exit various sites across London including its headquarters at 133 Holborn, WC1.
A source close to the deal said: “This is a positive statement made by Nationwide and it is a good sign for the market.”
Savills and CBRE advised SEB; Colliers International acted Nationwide.
All parties declined to comment.