The GLA has awarded nine areas of London special housing zone status and allocated £260m to help them build 28,000 homes in the next decade.
There are 52 schemes in the nine zones, 28 of which have development partners in place and most of which already have planning.
The zones include Abbey Wood and South Thamesmead; Abbey Wood, Plumstead and Thamesmead; Barking town centre; Clapham Junction; Heart of Harrow; Hounslow town centre; New Bermondsey; Southall; and Tottenham.
The GLA plans to allocate 20 zones in total as part of a £400m programme to deliver 50,000 homes in the capital.
Deputy mayor for housing Richard Blakeway said: “This is the largest regeneration programme since the GLA was set up. It is a new bespoke way of working with boroughs to maximise the opportunities for development in some of the areas of London that need it most.”
The funding will help unlock wider regeneration projects in key areas of London.
In Clapham Junction it will be used to assist the redevelopment of the York Road and Winstanley council estates next to the station.
Network Rail and Arup are currently examining options for a major redevelopment of the station that could accommodate at least 2,000 homes, while Delancey owns a site next door.
A combined scheme would be among the largest residential-led regeneration projects in the capital.
The boroughs will lead the procurement of partners for sites that do not yet have development partners.
They will also dictate the nature of development, with some areas, such as Tottenham Hale, keen to prioritise affordable housing, while others, such as Barking, want to build private rented homes.
In some instances money will be lent to developers on a commercial basis to kick-start development; in others it will be spent on infrastructure or public procurement.