The Old Oak Park Royal Development Corporation has approved plans for the High Speed 2 station at Old Oak Common, NW10.
The station will be the first phase of development, kick-starting one of the largest regenerations in the UK.
The Old Oak redevelopment seeks to provide 25,500 new homes and 65,000 jobs on former railway and industrial land.
The £26bn redevelopment has faced a number of barriers in the past year, with the loss of a potential 54 acres of land owned by Cargiant and lack of funds forcing it to turn away a £250m grant from the Housing Infrastructure Fund.
Last year it said it would instead look to partner with landowners including Network Rail and HS2 to bring forward individual parcels.
OPDC chair Liz Peace said: “Now, more so than ever, the delivery of new and affordable homes and jobs at Old Oak and Park Royal is needed to capitalise on the unrivalled connectivity that HS2 will bring.”
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